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    Rabbit Anti-EMP-1 antibody (bs-0558R)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
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    產品編號 bs-0558R
    英文名稱 EMP-1
    中文名稱 表皮膜蛋白1抗體
    別    名 CL-20; EMP 1; EMP1; EMP1_HUMAN; Epithelial membrane protein 1; Protein B4B; TMP; Tumor-associated membrane protein.  
    Specific References  (1)     |     bs-0558R has been referenced in 1 publications.
    [IF=20.722] Shaojun Peng. et al. Second near-infrared photoactivatable hydrogen selenide nanogenerators for metastasis-inhibited cancer therapy. Nano Today. 2021 Oct;40:101240  IF ;  Mouse.  
    研究領域 細胞生物  免疫學  細胞凋亡  細胞膜受體  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Rat,  (predicted: Mouse, )
    產品應用 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 17kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from mouse EMP-1: 101-160/160 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 Epithelial membrane protein-1 (EMP-1) is a four pass transmembrane protein consisting of 160 amino acids. It is a member of a small family of epithelial membrane proteins. EMP-1 is very similar in structure to its close relative, Peripheral Myelin Protein 22 (PMP22). It is most predominantly expressed in tissues of the gastrointestinal tract but has also been found to be a junctional protein in the liver expressed along the intercellular border. EMP-1 directly interacts with the C-terminus of the P2X7 receptor and may be involved in membrane blebbing. EMP-1 may also be an important regulator in cell communication, signaling, and adhesion. When EMP-1 is overexpressed, cell proliferation is inhibited, S phase is arrested and G1 phase is prolonged in esophogeal cancer cells. EMP-1 may play a role in tumorigenesis and has been identified as a biomarker for gefitinib treatment resistance for patients with lung cancer.

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.

    Similarity:
    Belongs to the PMP-22/EMP/MP20 family.

    SWISS:
    P47801

    Gene ID:
    13730

    Database links:

    Entrez Gene: 2012 Human

    Omim: 602333 Human

    SwissProt: P54849 Human

    Unigene: 719042 Human



    emp-1蛋白主要參與細胞生長發育、細胞增殖、死亡、表皮發育等作用。
    產品圖片
    Blank control: A431.
    Primary Antibody (green line): Rabbit Anti-EMP-1 antibody (bs-0558R)
    Dilution: 3μg /10^6 cells;
    Isotype Control Antibody (orange line): Rabbit IgG .
    Secondary Antibody: Goat anti-rabbit IgG-AF647
    Dilution: 3μg /test.
    Protocol
    The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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