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    Rabbit Anti-CD40L antibody (bs-1286R)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
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    產品編號 bs-1286R
    英文名稱 CD40L
    中文名稱 CD40L(CD154)抗體
    別    名 TNFSF5; CD 154; CD154; CD 40L; CD154 antigen; CD40 homologue; CD40 ligand; CD40LG; gp39; hCD40L; HIGM1; Hyper IgM syndrome; IGM; IMD3; Ly62; T B cell activating molecule; T cell antigen GP39; TBAM; TNF related activation protein; TNF superfamily member 5; Tnfsf5; TRAP; Tumor necrosis factor (ligand) superfamily member 5; CD40L_HUMAN.   
    Specific References  (5)     |     bs-1286R has been referenced in 5 publications.
    [IF=0] Rui-Kai and Jian Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats. (2012) Int.J.Rheumato. 2012:139696  FC/FACS ;  Rat.  
    [IF=3.455] Jennifer A. Schreiber. et al. Moderate blood alcohol and brain neurovulnerability: Selective depletion of calcium-independent PLA2, omega-3 docosahexaenoic acid and its synaptamide derivative as a potential harbinger of deficits in anti-inflammatory reserve. 2021 Nov 01  WB ;  Rat,Mouse.  
    [IF=6.304] Chen Y et al. Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death Dis. 2020 Jun 2;11(6):414.  WB ;  Mouse.  
    [IF=2.895] Wang B et al. Anti‐Adhesive, Platelet Gathering Effects of c‐RGD Modified Poly (p‐dioxanone‐co‐l‐Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis. Macromol Biosci. 2019 Dec 18:e1900344.  IHC ;  Rat.  
    [IF=3.166] Zhang, Feng, et al. "BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor." Acta Pharmacologica Sinica (2016).  WB ;  Mouse.  
    研究領域 細胞生物  免疫學  信號轉導  細胞凋亡  細胞膜受體  細胞表面分子  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Rat, 
    產品應用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 29kDa
    檢測分子量 32-39 kDa
    細胞定位 細胞膜 分泌型蛋白 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD40L: 31-150/261 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

    Function:
    Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

    Subcellular Location:
    Secreted and Cell membrane.

    Tissue Specificity:
    Specifically expressed on activated CD4+ T-lymphocytes.

    DISEASE:
    Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.

    Similarity:
    Belongs to the tumor necrosis factor family.

    SWISS:
    P29965

    Gene ID:
    959

    Database links:

    Entrez Gene: 959 Human

    Entrez Gene: 21947 Mouse

    Entrez Gene: 84349 Rat

    Omim: 300386 Human

    SwissProt: P29965 Human

    SwissProt: P27548 Mouse

    SwissProt: Q9Z2V2 Rat

    Unigene: 592244 Human

    Unigene: 4861 Mouse

    Unigene: 44218 Rat



    CD40L也是T細胞活化的重要輔助刺激通路,不僅在調節T細胞免疫反應中起關鍵作用,而且也在B細胞的活化、增殖、分化、抗體的分泌起重要作用。主要表達在B細胞,有抗凋亡和促生長、分化的作用。
    產品圖片
    Paraformaldehyde-fixed, paraffin embedded (human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD40L) Polyclonal Antibody, Unconjugated (bs-1286R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (rat spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD40L) Polyclonal Antibody, Unconjugated (bs-1286R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (rat spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD40L) Polyclonal Antibody, Unconjugated (bs-1286R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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