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    Rabbit Anti-Syndecan-1 antibody (bs-1309R)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
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    產品編號 bs-1309R
    英文名稱 Syndecan-1
    中文名稱 多配體蛋白聚糖1(CD138)抗體
    別    名 SDC1; SDC; SYND1; Syndecan I; SyndecanI; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.  
    Specific References  (6)     |     bs-1309R has been referenced in 6 publications.
    [IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.  
    [IF=5.733] Jiang Yufei. et al. Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation. Hum Reprod. 2020 Nov;35(11):2439-2453  IP ;  Human.  
    [IF=4.831] Linlin Yanget al. CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis. Aging (Albany NY) . 2020 Jul 13;12(13):13668-13683.  IHC, IF ;  Human.  
    [IF=2.97] Hambruch, N., et al. "Bovine placentomal heparanase and syndecan expression is related to placental maturation." Placenta.  IHC-P ;  Bovine.  
    [IF=2.54] Chen, Song, et al. "Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis." Journal of Histochemistry & Cytochemistry (2017): 0022155417692536.  IHC-P ;  Mouse.  
    [IF=2.65] Miyatani, Kozo, et al. "A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis." Virchows Archiv (2016): 1-9.  IHC-F ;  Human.  
    研究領域 腫瘤  神經生物學  細胞膜受體  細胞粘附分子  細胞表面分子  糖蛋白  上皮細胞  內皮細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Rat, Cow,  (predicted: Mouse, Chicken, Dog, Pig, Horse, Rabbit, )
    產品應用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 34kDa
    檢測分子量 50 kDa
    細胞定位 細胞膜 分泌型蛋白 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD138: 201-310/310 <Cytoplasmic>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

    Function:
    Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

    Subunit:
    Interacts with CDCP1.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

    Post-translational modifications:
    Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

    Similarity:
    Belongs to the syndecan proteoglycan family.

    SWISS:
    P18827

    Gene ID:
    6382

    Database links:

    Entrez Gene: 6382 Human

    Entrez Gene: 20969 Mouse

    Entrez Gene: 25216 Rat

    Omim: 186355 Human

    SwissProt: P18827 Human

    SwissProt: P18828 Mouse

    SwissProt: P26260 Rat

    Unigene: 224607 Human

    Unigene: 665958 Human

    Unigene: 2580 Mouse

    Unigene: 11176 Rat



    Syndecan1(CD138)屬于Syndecans基因家族,該家族是一類細胞表面跨膜蛋白多糖 ,是膜表面粘附受體 ,參與細胞-細胞外基質之間的粘附。
    CD138表達于上皮細胞、胚胎間質細胞、血管平滑肌細胞、內皮細胞和神經細胞基底膜。Syndecan-1與惡性腫瘤的發生發展、浸潤及轉移有關,著色于胞漿和胞膜.
    產品圖片
    Sample:
    JEG-3(Human) Cell Lysate at 30 ug
    Primary: Anti-Syndecan-1 (bs-1309R) at 1/500 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 34 kD
    Observed band size: 34 kD
    Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
    Blank control: Hela(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice.
    Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 1μg in 100 μL1X PBS containing 0.5% BSA(green).
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