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    產品編號 bs-0979R
    英文名稱 CD38
    中文名稱 CD38抗體
    別    名 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN; CD38_MOUSE; I-19; NIM-R5 antigen.  
    Specific References  (3)     |     bs-0979R has been referenced in 3 publications.
    [IF=14.919] Jinfeng Wang. et al. Translocation of vaginal microbiota is involved in impairment and protection of uterine health. Nat Commun. 2021 Jul;12(1):1-15  IF ;  Rat.  
    [IF=4.966] Santoshi Muppalaet al. The P387 thrombospondin‐4 variant promotes accumulation of macrophages in atherosclerotic lesions. FASEB J . 2020 Sep;34(9):11529-11545.  IHC, IF ;  mouse.  
    [IF=1.257] Moridera K et al. Skeletal unloading reduces cluster of differentiation (CD) 38 expression in the bone marrow and osteoblasts of mice. J Orthop Sci.?2019 May 6.  ICC ;  Mouse.  
    研究領域 腫瘤  免疫學  干細胞  糖尿病  細胞表面分子  自然殺傷細胞  淋巴細胞  t-淋巴細胞  b-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse, Rat, 
    產品應用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 34kDa
    檢測分子量 45kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from mouse CD38: 101-200/304 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

    Function:
    Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

    Subcellular Location:
    Membrane; Single-pass type II membrane protein.

    Tissue Specificity:
    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

    Similarity:
    Belongs to the ADP-ribosyl cyclase family.

    SWISS:
    P56528

    Gene ID:
    12494

    Database links:

    Entrez Gene: 952 Human

    Entrez Gene: 12494 Mouse

    Omim: 107270 Human

    SwissProt: P28907 Human

    SwissProt: P56528 Mouse

    Unigene: 479214 Human

    Unigene: 249873 Mouse



    CD38分子是單鏈Ⅱ型跨膜糖蛋白,存在于很多免疫細胞表面上,CD38與無脊椎動物卵的授精、HIV感染、某些癌癥以及糖尿病等有關,CD38具有許多復雜而又獨特的生物學特性及功能,有調控細胞鈣釋放的機制。主要表達于胸腺細胞、前T和前B細胞、活化的T和B細胞、單核細胞、NK細胞、漿細胞等,可用于急性白血病的分型和活化的T細胞在自身免疫和免疫缺陷中的作用等方面的研究,也可作為生發中心B細胞的一種選擇性標記。
    產品圖片
    Sample:
    Cerebrum (Rat) Lysate at 40 ug
    Primary: Anti-CD38 (bs-0979R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 34 kD
    Observed band size: 48 kD
    Sample:
    SP2/0(Mouse) Cell Lysate at 30 ug
    Primary: Anti-CD38 (bs-0979R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 34 kD
    Observed band size: 54 kD
    Sample:
    Pancreas (Mouse) Lysate at 40 ug
    Primary: Anti-CD38 (bs-0979R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 34 kD
    Observed band size: 48 kD
    Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    Incubation: Anti-CD38 Polyclonal Antibody, Unconjugated(bs-0979R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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