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    產品編號 bs-2490R
    英文名稱 CD23
    中文名稱 CD23/FcεRII抗體
    別    名 Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219.  
    研究領域 細胞生物  免疫學  干細胞  細胞類型標志物  淋巴細胞  t-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse,  (predicted: Rat, Horse, Rabbit, )
    產品應用 WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 36kDa
    細胞定位 細胞膜 分泌型蛋白 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD23: 221-321/321 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

    Function:
    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

    Post-translational modifications:
    N- and O-glycosylated.

    Similarity:
    Contains 1 C-type lectin domain.

    SWISS:
    P06734

    Gene ID:
    2208

    Database links:

    Entrez Gene: 2208 Human

    Entrez Gene: 14128 Mouse

    Omim: 151445 Human

    SwissProt: P06734 Human

    SwissProt: P20693 Mouse

    Unigene: 465778 Human

    Unigene: 1233 Mouse



    CD23是一種II型跨膜糖蛋白,是存在于B細胞表面的IgE受體。在慢性B淋巴細胞白血?。–LL)和小B細胞淋巴瘤(SLL)為陽性,套細胞淋巴瘤和小核裂淋巴細胞淋巴瘤陰性。也表達于外周血B細胞的某些亞型、B淋巴細胞和EB病毒轉染的B淋巴瘤細胞系。CD23是慢性B淋巴細胞白血病,小B細胞淋巴瘤診斷和鑒別診斷有用的標記物。
    產品圖片
    Sample:
    293T Cell (Human) Lysate at 30 ug
    Primary: Anti- CD23 (bs-2490R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 36 kD
    Observed band size: 50/40 kD
    Sample:
    Spleen (Mouse) Lysate at 40 ug
    Primary: Anti- CD23 (bs-2490R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 36 kD
    Observed band size: 50/40 kD
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