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    產品編號 bs-2517R
    英文名稱 CD72
    中文名稱 CD72蛋白抗體
    別    名 B-cell differentiation antigen CD72; CD72b; B cell differentiation antigen CD72; CD72 antigen; CD72 molecule; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873; CD72_HUMAN.  
    研究領域 腫瘤  免疫學  干細胞  細胞表面分子  糖蛋白  b-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human,  (predicted: Mouse, Rat, Dog, Cow, )
    產品應用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 40kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD72: 4-110/359 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.

    Function:
    Plays a role in B-cell proliferation and differentiation.

    Subunit:
    Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

    Subcellular Location:
    Membrane; Single-pass type II membrane protein.

    Tissue Specificity:
    Pre-B-cells and B-cells but not terminally differentiated plasma cells.

    Post-translational modifications:
    Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).

    Similarity:
    Contains 1 C-type lectin domain.

    SWISS:
    P21854

    Gene ID:
    971

    Database links:

    Entrez Gene: 971 Human

    Omim: 107272 Human

    SwissProt: P21854 Human

    Unigene: 116481 Human



    CD72是一個重要的B細胞特異性受體。屬于II型膜內糖蛋白成員中的細胞表面分子非唾液酸糖蛋白受體,雖然其分子功能目前還不清楚,但目前發現CD72的多態性與多種腫瘤有關。
    產品圖片
    Blank control(blue):Raji cells (fixed with 2% paraformaldehyde (10 min)) .
    Primary Antibody:Rabbit Anti- CD72 antibody(bs-2517R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
    Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
    Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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