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    產品編號 bs-4869R
    英文名稱 CD20
    中文名稱 CD20抗體
    別    名 CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7.  
    Specific References  (1)     |     bs-4869R has been referenced in 1 publications.
    [IF=3.156] Lili Feng. et al. NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma. Leukemia Res. 2021 Sep;:106708  IHC ;  mouse.  
    研究領域 腫瘤  免疫學  干細胞  細胞表面分子  細胞類型標志物  淋巴細胞  b-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, )
    產品應用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-200 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 33kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD20: 51-150/297 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.

    Function:
    This protein may be involved in the regulation of B-cell activation and proliferation.

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Expressed on B-cells.

    Post-translational modifications:
    Phosphorylated. Might be functionally regulated by protein kinase(s).

    DISEASE:
    Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

    Similarity:
    Belongs to the MS4A family.

    SWISS:
    P11836

    Gene ID:
    931

    Database links:

    Entrez Gene: 931 Human

    Omim: 112210 Human

    SwissProt: P11836 Human

    Unigene: 712553 Human



    CD20是B細胞特異性抗原,其表達呈細胞類型一種質膜蛋白質,參與信號傳導作用,此抗體識別大多數B細胞上的一種抗原。多用于標記B淋巴細胞及B細胞淋巴瘤。 CD20一般不與T細胞交叉反應,對B細胞淋巴瘤和急慢性淋巴細胞白血病等有較好的細胞特異性,因此在惡性淋巴瘤,尤其是T或B細胞淋巴瘤的分類上,CD20是最常用的B細胞標志。
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