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    產品編號 bs-10218R
    英文名稱 CD5
    中文名稱 CD5抗體
    別    名 T-cell surface glycoprotein CD5; Lymphocyte antigen 1; Ly-1; Lyt-1; CD-5; CD5 antigen; CD 5; CD5 molecule; CD5 antigen (p56 62); CD5_HUMAN; LEU 1; LEU1; Ly12; LyA; Lymphocyte Antigen CD5; Lymphocyte antigen T1/Leu 1; Lymphocyte antigen T1/Leu-1; Lymphocyte glycoprotein T1/Leu1; OTTHUMP00000236973; p56 62; T1.  
    Specific References  (1)     |     bs-10218R has been referenced in 1 publications.
    [IF=2.751] Jiachen Lv. et al. Alcohol Aggravates Acute Pancreatitis by Impairing Autophagic Flux Through Activation of AMPK Signaling Pathway. 2021 Feb 08  IHC ;  Human,Rat.  
    研究領域 免疫學  干細胞  細胞表面分子  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse, Rat,  (predicted: Cow, Horse, Rabbit, Sheep, )
    產品應用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 55kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD5: 221-320/495 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.

    Function:
    May act as a receptor in regulating T-cell proliferation.

    Subunit:
    Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.

    Subcellular Location:
    Cell membrane; Single-pass type I membrane protein.

    Post-translational modifications:
    Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

    Similarity:
    Contains 3 SRCR domains.

    SWISS:
    P06127

    Gene ID:
    921

    Database links:

    Entrez Gene: 921 Human

    Omim: 153340 Human

    SwissProt: P06127 Human

    Unigene: 58685 Human




    產品圖片
    Sample:
    Lymph node (Mouse) Lysate at 40 ug
    Primary: Anti-CD5 (bs-10218R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 55 kD
    Observed band size: 55 kD
    Sample:
    Jurkat(Human) Cell Lysate at 30 ug
    MOLT-4(Human) Cell Lysate at 30 ug
    293T(Human) Cell Lysate at 30 ug
    Primary: Anti-CD5 (bs-10218R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 55 kD
    Observed band size: 55 kD
    Sample:
    Thymus (Mouse) Lysate at 40 ug
    Lymph node (Mouse) Lysate at 40 ug
    Primary: Anti-CD5 (bs-10218R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 55 kD
    Observed band size: 55 kD
    Molt-4 cells were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with CD5 Antibody(bs-10218R)at 1:500 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).
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