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    Rabbit Anti-CD19 antibody (bs-20781R)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
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    產品編號 bs-20781R
    英文名稱 CD19
    中文名稱 CD19抗體
    別    名 CD19_HUMAN; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19; B-lymphocyte surface antigen B4; Leu 12; Leu12;   
    研究領域 細胞生物  免疫學  干細胞  細胞表面分子  淋巴細胞  b-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, 
    產品應用 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 59kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD19: 121-200/556 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

    Function:
    Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

    Subunit:
    Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein.

    Post-translational modifications:
    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.

    DISEASE:
    Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

    Similarity:
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    SWISS:
    P15391

    Gene ID:
    930

    Database links:

    Entrez Gene: 930 Human

    Entrez Gene: 12478 Mouse

    Entrez Gene: 365367 Rat

    Omim: 107265 Human

    SwissProt: P15391 Human

    SwissProt: P25918 Mouse

    Unigene: 652262 Human

    Unigene: 4360 Mouse



    CD19是一種質膜蛋白質,參與信號傳導作用。表達與前B細胞和成熟的B細胞膜表面,與B細胞的活化調節和發育調節相關,在T細胞和正常粒細胞上無表達。此抗體可以特異性識別CD19,主要用于標記正常B細胞及腫瘤性B細胞。
    產品圖片
    Blank control (blue line): HL60 cells (fixed with 70% methanol (Overnight at 4℃) . Cells stained with Primary Antibody for 30 min at room temperature).
    Primary Antibody (green line): Rabbit Anti-CD19 antibody (bs-20781R),Dilution: 0.2 μg /10^6 cells;
    Isotype Control Antibody (orange line): Rabbit IgG .
    Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.
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