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    Mouse Anti-CD23 antibody (bsm-33088M)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
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    產品編號 bsm-33088M
    英文名稱 CD23
    中文名稱 CD23/FcεRII單克隆抗體
    別    名 Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219.  
    研究領域 細胞生物  免疫學  b-淋巴細胞  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 12G2
    交叉反應 Human,  (predicted: Mouse, Rat, )
    產品應用 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 36kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 Recombinant human CD23 
    亞    型 IgG
    純化方法 affinity purified by Protein G
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

    Function:
    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

    Post-translational modifications:
    N- and O-glycosylated.

    Similarity:
    Contains 1 C-type lectin domain.

    SWISS:
    P06734

    Gene ID:
    2208

    Database links:

    Entrez Gene: 2208 Human

    Entrez Gene: 14128 Mouse

    Omim: 151445 Human

    SwissProt: P06734 Human

    SwissProt: P20693 Mouse

    Unigene: 465778 Human

    Unigene: 1233 Mouse



    CD23是一種II型跨膜糖蛋白,是存在于B細胞表面的IgE受體。在慢性B淋巴細胞白血?。–LL)和小B細胞淋巴瘤(SLL)為陽性,套細胞淋巴瘤和小核裂淋巴細胞淋巴瘤陰性。也表達于外周血B細胞的某些亞型、B淋巴細胞和EB病毒轉染的B淋巴瘤細胞系。CD23是慢性B淋巴細胞白血病,小B細胞淋巴瘤診斷和鑒別診斷有用的標記物。
    產品圖片
    Paraformaldehyde-fixed, paraffin embedded (Human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD23) Monoclonal Antibody, Unconjugated (ascites of bsm-33088M 12G2) at 1:2000 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructions and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (human tonsil tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD23) Monoclonal Antibody, Unconjugated (ascites of bsm-33088M) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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