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    Mouse Anti-CD10 antibody (bsm-33078M)
    訂購QQ:  400-901-9800
    說明書: 50ul  100ul  
    產品編號 bsm-33078M
    英文名稱 CD10
    中文名稱 CD10單克隆抗體
    別    名 NEP_HUMAN; Neprilysin; MME; membrane metalloendopeptidase; NEP; SFE; CD10; CALLA; CMT2T; SCA43; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; Neutral endopeptidase; Skin fibroblast elastase;   
    研究領域 腫瘤  免疫學  干細胞  細胞膜受體  細胞表面分子  細胞類型標志物  b-淋巴細胞  新陳代謝  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 7C8
    交叉反應 (predicted: Human, Mouse, Rat, )
    產品應用 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 82kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD10 
    亞    型 IgG
    純化方法 affinity purified by Protein G
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

    Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein.

    Post-translational modifications:
    Myristoylation is a determinant of membrane targeting.
    Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.

    Belongs to the peptidase M13 family.


    Gene ID:

    Database links:

    Entrez Gene: 4311 Human

    Entrez Gene: 17380 Mouse

    Entrez Gene: 24590 Rat

    Omim: 120520 Human

    SwissProt: P08473 Human

    SwissProt: Q61391 Mouse

    SwissProt: P07861 Rat

    Unigene: 307734 Human

    Unigene: 296022 Mouse

    Unigene: 33598 Rat

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