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    Mouse Anti-CD10 antibody (bsm-33078M)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
    訂購熱線:400-901-9800
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    說明書: 50ul  100ul  
    50ul/1138.00元
    100ul/1880.00元
    大包裝/詢價
    產品編號 bsm-33078M
    英文名稱 CD10
    中文名稱 CD10單克隆抗體
    別    名 NEP_HUMAN; Neprilysin; MME; membrane metalloendopeptidase; NEP; SFE; CD10; CALLA; CMT2T; SCA43; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; Neutral endopeptidase; Skin fibroblast elastase;   
    研究領域 腫瘤  免疫學  干細胞  細胞膜受體  細胞表面分子  細胞類型標志物  b-淋巴細胞  新陳代謝  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 7C8
    交叉反應 (predicted: Human, Mouse, Rat, )
    產品應用 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 82kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD10 
    亞    型 IgG
    純化方法 affinity purified by Protein G
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

    Function:
    Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein.

    Post-translational modifications:
    Myristoylation is a determinant of membrane targeting.
    Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.

    Similarity:
    Belongs to the peptidase M13 family.

    SWISS:
    P08473

    Gene ID:
    4311

    Database links:

    Entrez Gene: 4311 Human

    Entrez Gene: 17380 Mouse

    Entrez Gene: 24590 Rat

    Omim: 120520 Human

    SwissProt: P08473 Human

    SwissProt: Q61391 Mouse

    SwissProt: P07861 Rat

    Unigene: 307734 Human

    Unigene: 296022 Mouse

    Unigene: 33598 Rat



    CD10即共同型急性淋巴細胞白血病抗原,是II型跨膜糖蛋白.CD10表達于早期B淋巴細胞,某些粒性白細胞,骨髓基質細胞,部分上皮組織及其起源的腫瘤細胞中也有表達.主要應用于某些惡性淋巴瘤和白血病的分型.CD10是一種94kD的鋅依賴性細胞膜金屬結合蛋白,參與細胞神經肽和激素肽的后分泌過程。它廣泛地分布于腎、肝、小腸、胎盤、脈絡膜叢、腦腺、腺皮質和白細胞,CD10是生發中心細胞及所致淋巴瘤的標志物。
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