• <li id="2m8eg"></li>
  • <tt id="2m8eg"><blockquote id="2m8eg"></blockquote></tt>
  • 掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
    客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯系我們
    產品中心-北京博奧森生物技術有限公司
    首頁 > 產品中心 > 一抗 > 產品信息
    Rabbit Anti-CD24  antibody (bs-23867R)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說明書: 50ul  100ul  200ul
    50ul/1138.00元
    100ul/1880.00元
    200ul/2900.00元
    大包裝/詢價

    產品編號 bs-23867R
    英文名稱 CD24
    中文名稱 CD24抗體
    別    名 CD 24; CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24_HUMAN; CD24A; GPI linked surface mucin; Heat stable antigen; HSA; Nectadrin; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; Cd24; Cd24a; Ly-52.  
    研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞粘附分子  糖蛋白  細胞類型標志物  t-淋巴細胞  b-淋巴細胞  骨髓細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse, Rat, 
    產品應用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 3/8kDa
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD24 : 35-80/80 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.

    Function:
    Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

    Subcellular Location:
    Cell membrane; Lipid-anchor, GPI-anchor.

    Tissue Specificity:
    B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

    DISEASE:
    Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

    Similarity:
    Belongs to the CD24 family.

    SWISS:
    P25063

    Gene ID:
    100133941

    Database links:

    Entrez Gene: 100133941 Human

    Entrez Gene: 12484 Mouse

    Entrez Gene: 25145 Rat

    Omim: 600074 Human

    SwissProt: P25063 Human

    SwissProt: P24807 Mouse

    SwissProt: Q07490 Rat

    Unigene: 644105 Human

    Unigene: 721443 Human

    Unigene: 29742 Mouse

    Unigene: 6007 Rat



    神經干細胞標志物 腫瘤標志物 CD24是一種低分子質量高度糖基化的黏附分子, 主要表達在造血系統. 最近研究表明, 在造血系統腫瘤和一些器官的實體瘤表面可見CD24高表達。近幾年很多學者認為:CD24在前列腺癌、非小細胞肺癌、鼻咽癌、原發性肝細胞癌、膽管細胞癌、麥克爾細胞癌、神經源性腫瘤、胰腺癌、胃癌、結腸癌、腎細胞癌、B細胞淋巴瘤、乳腺癌等腫瘤組織中表達增強, 且和腫瘤侵襲轉移、復發和預后相關。
    產品圖片
    Sample:
    Lane 1: Kidney (Mouse) Lysate at 40 ug
    Lane 2: Cerebrum (Mouse) Lysate at 40 ug
    Lane 3: Kidney (Rat) Lysate at 40 ug
    Lane 4: Cerebrum (Rat) Lysate at 40 ug
    Primary:
    Anti- CD24 (bs-23867R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 35 kD
    Observed band size: 35 kD
    版權所有 2019-2022 www.gesunde-tips.com 北京博奧森生物技術有限公司
    通過國際質量管理體系ISO9001:2008 GB/T19001-2008認證    編號:00115Q211807R1M/1100
    京ICP備05066980號-1         京公網安備110107000727號
    欧美粗大猛烈老熟妇_成·人免费午夜无码视频夜色_午夜无码伦费影视在线观看_国产野战无套av毛片