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    Mouse Anti-human CD4 antibody (bsm-30093M)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說明書: 100ug  
    100ug/1880.00元
    大包裝/詢價
    產品編號 bsm-30093M
    英文名稱 human CD4
    中文名稱 小鼠抗人CD4單克隆抗體
    別    名 LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HSA; HUTCH-I; HUTCH1; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP-1; PGP1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD44 antigen isoform 1 precursor.  
    研究領域 腫瘤  細胞生物  免疫學  細胞表面分子  t-淋巴細胞  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 HIT4a
    交叉反應 (predicted: Human, )
    產品應用 Flow-Cyt= 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 48kDa
    檢測分子量 56
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD4 
    亞    型 Mouse IgG2b
    純化方法 Affinity purified by Protein G
    緩 沖 液 0.01M TBS(pH=7.4)
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].

    Function:
    Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

    Subunit:
    Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

    Subcellular Location:
    Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

    Post-translational modifications:
    Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

    Similarity:
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    SWISS:
    P01730

    Database links:

    Entrez Gene: 920 Human

    Entrez Gene: 12504 Mouse

    Omim: 186940 Human

    SwissProt: P06332 Mouse

    SwissProt: P01730 Human

    Unigene: 631659 Human

    Unigene: 2209 Mouse




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