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    Mouse Anti-human CD19 antibody (bsm-30096M)
    ~~~促銷,代碼KT22301~~~
    ~~~促銷,代碼KT22302~~~
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
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    說明書: 100ug  
    100ug/1880.00元
    大包裝/詢價

    產品編號 bsm-30096M
    英文名稱 human CD19
    中文名稱 小鼠抗人CD19單克隆抗體
    別    名 CD19_HUMAN; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19; B-lymphocyte surface antigen B4; Leu 12; Leu12;  
    研究領域 細胞生物  免疫學  細胞表面分子  b-淋巴細胞  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 HI19a
    交叉反應 (predicted: Human, )
    產品應用 Flow-Cyt= 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 59kDa
    檢測分子量 90
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD19 
    亞    型 Mouse IgG1
    純化方法 Affinity purified by Protein G
    緩 沖 液 0.01M TBS(pH=7.4)
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

    Function:
    Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

    Subunit:
    Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein.

    Post-translational modifications:
    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.

    DISEASE:
    Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

    Similarity:
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    SWISS:
    P15391

    Database links:

    Entrez Gene: 930 Human

    Entrez Gene: 12478 Mouse

    Entrez Gene: 365367 Rat

    Omim: 107265 Human

    SwissProt: P15391 Human

    SwissProt: P25918 Mouse

    Unigene: 652262 Human

    Unigene: 4360 Mouse



    產品圖片
    scatter diagram showing peripheral blood lymphocytes stained with bsm-30096M. The cells were incubated with the antibody (bsm-30096M, 5 μl/Test) for 30 min at 22°C. The secondary antibody used for 40 min at room temperature Acquisition of >10,000 events was performed.
    scatter diagram showing peripheral blood lymphocytes stained with bsm-30096M. The cells were incubated with the antibody (bsm-30096M, 5 μl/Test) for 30 min at 22°C. The secondary antibody used for 40 min at room temperature Acquisition of >10,000 events was performed.
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