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    Rabbit Anti-CD38/Biotin Conjugated antibody (bs-0979R-Bio)
    ~~~促銷,代碼SQ220725~~~
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-0979R-Bio
    英文名稱 Anti-CD38/Biotin
    中文名稱 生物素標記的CD38抗體
    別    名 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN; CD38_MOUSE; I-19; NIM-R5 antigen.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 腫瘤  免疫學  干細胞  糖尿病  細胞表面分子  自然殺傷細胞  淋巴細胞  t-淋巴細胞  b-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Mouse, Rat, 
    產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 34kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from mouse CD38
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

    Function:
    Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

    Subcellular Location:
    Membrane; Single-pass type II membrane protein.

    Tissue Specificity:
    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

    Similarity:
    Belongs to the ADP-ribosyl cyclase family.

    Database links:

    Entrez Gene: 952 Human

    Entrez Gene: 12494 Mouse

    Omim: 107270 Human

    SwissProt: P28907 Human

    SwissProt: P56528 Mouse

    Unigene: 479214 Human

    Unigene: 249873 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    CD38分子是單鏈Ⅱ型跨膜糖蛋白,存在于很多免疫細胞表面上,CD38與無脊椎動物卵的授精、HIV感染、某些癌癥以及糖尿病等有關,CD38具有許多復雜而又獨特的生物學特性及功能,有調控細胞鈣釋放的機制。主要表達于胸腺細胞、前T和前B細胞、活化的T和B細胞、單核細胞、NK細胞、漿細胞等,可用于急性白血病的分型和活化的T細胞在自身免疫和免疫缺陷中的作用等方面的研究,也可作為生發中心B細胞的一種選擇性標記。
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