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    Rabbit Anti-CD23/PE-Cy7 Conjugated antibody (bs-2490R-PE-Cy7)
    訂購QQ:  400-901-9800
    說 明 書: 100ul  
    產品編號 bs-2490R-PE-Cy7
    英文名稱 Anti-CD23/PE-Cy7
    中文名稱 PE-Cy7標記的CD23/FcεRII抗體
    別    名 Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  免疫學  干細胞  細胞類型標志物  淋巴細胞  t-淋巴細胞  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse,  (predicted: Rat, Horse, Rabbit, )
    產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 36kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD23
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

    Post-translational modifications:
    N- and O-glycosylated.

    Contains 1 C-type lectin domain.

    Database links:

    Entrez Gene: 2208 Human

    Entrez Gene: 14128 Mouse

    Omim: 151445 Human

    SwissProt: P06734 Human

    SwissProt: P20693 Mouse

    Unigene: 465778 Human

    Unigene: 1233 Mouse

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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